Elevated rates of sister chromatid exchange at chromosome ends

Citations of this article
Mendeley users who have this article in their library.


Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, respectively, than elsewhere in the genome. © 2007 Rudd et al.




Rudd, M. K., Friedman, C., Parghi, S. S., Linardopoulou, E. V., Hsu, L., & Trask, B. J. (2007). Elevated rates of sister chromatid exchange at chromosome ends. PLoS Genetics, 3(2), 0319–0323. https://doi.org/10.1371/journal.pgen.0030032

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free