Abstract
We examined the radioprotective effect of aminothiol 2-N-propylamine- cyclo-hexanethiol (20-PRA) on a human leukemic cell line (K562) following various radiation doses (5, 7.5 and 20 Gy) using a source of 60Co γ-rays. At 5 Gy and 1 nM 20-PRA, a substantial protective effect (58%) was seen 24 h after irradiation, followed by a decrease at 48 h (11%). At the high radiation dose (20 Gy) a low protective effect was also seen (35%). In addition, the antitumorigenic potential of 10 nM 20-PRA was shown by the inhibition of crown gall formation induced by Agrobacterium tumefaciens. The radioprotective potency of 20-PRA is 105-106 times higher than that of the aminothiol WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane) whose protective effect is in the 0.1 to 1.0 mM range.
Author supplied keywords
Cite
CITATION STYLE
Dolabela, M. F., Pereira, M. T., Salas, C. E., Steffani, G. M., Nelson, D. L., Piló-Veloso, D., & Lopes, M. T. P. (1998). The radioprotective effect of a new aminothiol (20-PRA). Brazilian Journal of Medical and Biological Research, 31(8), 1095–1098. https://doi.org/10.1590/S0100-879X1998000800010
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
