The radioprotective effect of a new aminothiol (20-PRA)

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Abstract

We examined the radioprotective effect of aminothiol 2-N-propylamine- cyclo-hexanethiol (20-PRA) on a human leukemic cell line (K562) following various radiation doses (5, 7.5 and 20 Gy) using a source of 60Co γ-rays. At 5 Gy and 1 nM 20-PRA, a substantial protective effect (58%) was seen 24 h after irradiation, followed by a decrease at 48 h (11%). At the high radiation dose (20 Gy) a low protective effect was also seen (35%). In addition, the antitumorigenic potential of 10 nM 20-PRA was shown by the inhibition of crown gall formation induced by Agrobacterium tumefaciens. The radioprotective potency of 20-PRA is 105-106 times higher than that of the aminothiol WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane) whose protective effect is in the 0.1 to 1.0 mM range.

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APA

Dolabela, M. F., Pereira, M. T., Salas, C. E., Steffani, G. M., Nelson, D. L., Piló-Veloso, D., & Lopes, M. T. P. (1998). The radioprotective effect of a new aminothiol (20-PRA). Brazilian Journal of Medical and Biological Research, 31(8), 1095–1098. https://doi.org/10.1590/S0100-879X1998000800010

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