A review of theoretical aspects of HLA and disease associations

Abstract

A number of antigens (alleles) of the human histocompatibility (HLA) system have been shown to be associated with a wide range of chronic diseases. Recently a great deal of interest has been shown in many of the theoretical aspects of HLA disease associations. These range from statistical problems of detecting significant associations to the development of models to determine the mode of inheritance of the disease. These models, as well as other features of HLA disease associations, will be reviewed in this paper. © 1981.