Responders vs. Non-responders to Cardiac Resynchronization Therapy

Abstract

More than two decades after the introduction of cardiac resynchronization therapy (CRT) into clinical practice, there was still a challenge to get the expected benefit for this therapy. There was a group of patients that had a good response to the therapy, its called responders group, and others who didn’t get expected response called non-responders group. This article will discuss indications for initiating a CRT, the definition of a response to a CRT, steps in response to a CRT, predictors of a CRT response, clinical judgment of patients who do not respond to CRTs, and elimination for possible reversible non-response causes. Here we have reviewed non-response CRTs in many ways. In short, multidisciplinary efforts are needed to overcome them because of the multifactorial causes of non-response (NR). So far, several factors have slowed the progress, such as limitations of NR consensus definitions and technology for therapeutic delivery.