Salivary Biomarkers in the Diagnosis of Diabetic Nephropathy - An Non- Invasive Approach

Abstract

Diabetic Nephropathy, is a condition that is characterized by loss of kidney function and mostly occurs in individuals with Diabetes Mellitus. The development of Diabetic Nephropathy is easier to treat if diagnosed in the early stage (appearance of an abnormal amount of salivary biomarkers). The conventional methods are mostly invasive and have many limitations like irregular monitoring of the glucose, creatinine, urea etc., Saliva is a multi-constituent biological fluid. It is one of the most abundant secretions and its collection is easy and non-invasive. With this novel idea, the present study aimed in estimating the salivary parameters in the diagnosis of diabetic nephropathy. The objective of the project is to reduce the dependence on hemodialysis and kidney transplantation of a person suffering from ESRD by estimation of glucose by GOD-POD method, creatinine by Jaffe's method and urea by Berthelot- Urease method.