Cytotoxic and growth inhibitory effect of ascorbic acid on cultured bovine vascular endothelial cells

Abstract

Ascorbic acid (AsA) is highly concentrated in vitreous in bovine, human as well as in other species. In order to evaluate the role of ascorbic acid as an ocular neovascularization inhibitor, we examined the effect of ascorbic acid on growth and survival of cultured vascular endothelial cells. When added to culture medium, high concentration of ascorbic acid (0.3 mM