A roadmap to precision medicine through post-genomic electronic medical records

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Abstract

The promise of integrating Electronic Medical Records (EMR) and genetic data for precision medicine has largely fallen short due to its omission of environmental context over time. Post-genomic data can bridge this gap by capturing the real-time dynamic relationship between underlying genetics and the environment. This perspective highlights the pivotal role of integrating EMR and post-genomics for personalized health, reflecting on lessons from past efforts, and outlining a roadmap of challenges and opportunities that must be addressed to realize the potential of precision medicine.

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Mendez, K. M., Reinke, S. N., Kelly, R. S., Chen, Q., Su, M., McGeachie, M., … Lasky-Su, J. A. (2025). A roadmap to precision medicine through post-genomic electronic medical records. Nature Communications , 16(1). https://doi.org/10.1038/s41467-025-56442-4

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