Risk factors for acquisition of extended spectrum beta lactamase producing escherichia coli and klebsiella pneumoniae in North-Indian hospitals

Abstract

Multidrug resistance and production of extended spectrum β-lactamases (ESBLs) by enteric gram negative rods in hospitals and community continue to be a matter of scientific concern. This retrospective study was executed to assess the prevalence of ESBL-producing Escherichia coli and Klebsiella pneumoniae at two North Indian hospitals and to determine the risk factors associated with the acquisition of these organisms. A total of 346 bacterial isolates were obtained. Of these, 48.27% (. n=. 167) were confirmed to be ESBL producers while 51.73% (. n=. 179) were non ESBL-producers. Among the ESBL producers, 55.69% (. n=. 93) were E. coli and 44.31% (. n=. 74) were K. pneumoniae. ESBL producing isolates showed co-resistance to multitude of antibiotics tested. Length of hospital stay (>3. days) and previous exposure to antibiotics were found as significant risk factors (. p=. 0.01 and 0.02) associated with the acquisition of ESBL-producing E. coli and K. pneumoniae isolates. Imipenem and meropenem can be suggested as drugs of choice in our study.