Synthesis of new 1,2,4-oxadiazoles carrying (1′,S,2′S)-t- butyloxycarbonyl-1-amino-2-methyl-1-butyl and (1′S)-t-butyloxycarbonyl- 1′-amino-1′-ethyl groups at C-5

Abstract

A facile and efficient synthesis of 3-aryl-5-[(1S)-t-butyloxycarbonyl-1- amino-(2S)-methyl-1-butyl)]-1,2,4-oxadiazoles 4a-f and 3-phenyl-5-[(1S)-t- butyloxycarbonyl-1-amino-1-ethyl]-1,2,4-oxadiazole 6 starting from arylamidoximes, N-t-Boc-L-isoleucine and N-t-Boc-L-alanine is decribed. The structures of the intermediates and final compounds have been deduced from spectroscopic data.