Potential Application of Picosecond Pulsed Electric Field (PPEF): Advanced Bioelectrical Technology for Potential COVID-19 Treatment

Abstract

As human knowledge has increased, the efficacy and precision of tools to solve clinical problems have also increased. The challenge of COVID-19 has posed a significant threat to human life and reflects the need to upgrade existing technologies and make treatments more precise. Since the corona virus particle is in the nanometer range, the need for a device with accuracy beyond the nanometer range is apparent to control and eliminate it. Using Picosecond Pulsed Electric Fields (PPEF) could be a good antiviral picotechnology candidate. PPEF energy can (1) increase the innate immunity function of polymorphonuclear neutrophils, (2) destroy bacteria and other pathogens, and (3) potentially inactivate viral particles. This characteristic of PPEFs has already been used in the food industry. Both PPEF and nanosecond PEF technology is being used to treat cancer in research animals and has reached the stage of pre-clinical and clinical human trials with use in clinical practice soon to follow. Applying advanced PPEF technology against COVID-19 should provide new opportunities for effective human antiviral treatment.