This study aimed to identify factors influencing the development of leprosy (Hansen's disease) in household contacts. A dynamic cohort was analyzed from 1987 to 1991 at the Hansen's Disease Department of the Oswaldo Cruz Foundation in Rio de Janeiro. The incidence rate was 0.01694 person-years of follow-up. Nevertheless, for subjects at the end of the first year of follow-up the incidence rate was 0.06385 (end of second year, 0.03299; end of third year, 0.02370; end of fourth year, 0.018622; and end of observation period, 0.01694). A stepwise multivariate logistic regression model was proposed to study the risk of developing leprosy, including co-prevalent cases, totaling 758 contacts. In the final model, the risk was associated with a negative Mitsuda skin test (OR = 3.093; CI 95% = 1.735-5.514), prior BCG vaccination (OR = 0.3802; CI 95% = 0.2151-0.66719), and multibacillary primary clinical form (OR = 2.547; CI 95% = 1.249-5.192). The results showed that both multibacillary leprosy and specific immune status are significant indicators for developing the disease in a cohort of household contacts.
CITATION STYLE
de Matos, H. J., Duppre, N., Alvim, M. F., MachadoVieira, L. M., Sarno, E. N., & Struchiner, C. J. (1999). Leprosy epidemiology in a cohort of household contacts in Rio de Janeiro (1987-1991). Cadernos de Saúde Pública / Ministério Da Saúde, Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública, 15(3), 533–542. https://doi.org/10.1590/s0102-311x1999000300010
Mendeley helps you to discover research relevant for your work.