Intrarenal antibiotic distribution in health and disease

Abstract

Intrarenal tissue drug distribution studies may ultimately provide a better understanding of the factors of importance in selecting the appropriate drug for treatment of renal infections and may contribute to a better understanding of the mechanisms underlying antibiotic nephrotoxicity. Data available at present are incomplete and often fragmentary, but further systematic study of the factors influencing intrarenal drug concentrations promises information of both therapeutic and toxicologic value.