Explainability and Trust in Deep Learning for Cancer Imaging: Systematic Barriers, Clinical Misalignment, and a Translational Roadmap

Abstract

Deep learning (DL) has transformed cancer imaging by enabling automated tumour detection, classification, and risk prediction. Despite impressive diagnostic performance, limited explainability and poor uncertainty calibration continue to restrict clinical integration. This review is guided by five research questions that examine the challenges, impact, and translational implications of explainable artificial intelligence (XAI) in oncology imaging. We identify key barriers to trust, including dataset bias, shortcut learning, opacity of convolutional neural networks, and workflow misalignment. Evidence suggests that explainable models can increase clinician confidence, reduce false positives, and improve collaborative decision-making when explanations are faithful, semantically meaningful, and uncertainty aware. We evaluate architectural strategies that embed interpretability such as concept-bottleneck models, prototype-based learning, and attention regularization along with post hoc techniques. Beyond performance metrics, we examine how interpretable AI aligns with clinical reasoning processes and analyse regulatory, ethical, and medico-legal considerations influencing deployment. The findings indicate that explainability alone is insufficient, durable trust requires epistemic alignment, prospective validation, lifecycle governance, and equity-focused evaluation. By reframing explainability as a structural design principle rather than a supplementary feature, this review outlines a pathway toward accountable and clinically dependable AI systems in oncology.