Evaluation of platelet indices in cases of spontaneous abortion and recurrent pregnancy loss

Abstract

Background: Spontaneous abortion is defined as a clinically recognized pregnancy loss before the 20th week of gestation, or an expulsion of an embryo weighing 500 g or less. .Pregnancy is a condition of hypercoagulation. study aimed to evaluate the change of platelet indices namely platelet count, platelet crit , platelet distribution width and mean platelet volume among patients . Methods: This study is observational case control study . participants were 135 and divided into three groups Group1: 45 women with spontaneous abortion. Group2: 45 women with recurrent pregnancy loss.Group3: 45 normally pregnant women Results At cut off 14.12, platelet distribution width diagnose abortion (P=0.008) with sensitivity, specificity, PPV, NPV and accuracy of 74.4%, 53.3%, 76.1%, 51.1%, 67.4% respectively.At cut off 6.98, Mean platelet volume diagnose abortion (P=0.002) with sensitivity, specificity, PPV, NPV and accuracy of 76.7%, 44.4%, 75.0%, 57.1%, 70.4% respectively. At cut off 0.31, Platelet crit diagnose abortion with sensitivity, specificity, PPV, NPV and accuracy of 31.1%, 97.8%, 96.6%, 41.5%, 53.3% respectively. There were univariate regression for value of platelet indices in prediction of abortion in the studied sample. Conclusions: Platelet indices are markers for the prediction of spontaneous abortion and recurrent pregnancy loss