Human interferon-γ enhances the expression of class I and class II major histocompatibility complex products in neoplastic cells more effectively than interferon-α and interferon-β

Abstract

Human interferon-γ was more effective than interferon-β or -α in stimulating production of immunoassociated antigens; HLA-A, -B, and -C; and β2-microglobulin in human M14 and Namalva cells. The comparison was made on the basis of antiviral units, and the stimulation could be abolished by treatment of the interferon-γ preparation with pH 2 or anti-interferon-γ serum.