Mortalin/GRP75 binds to complement C9 and plays a role in resistance to complement-dependent cytotoxicity

Abstract

Background: Mortalin was shown to contribute to removal of the complement membranolytic C5b-9 complex from the target cell surface. Results: Modulations of mortalin expression and activity affect deposition of C5b-9 and cell death. Conclusion: Mortalin, through its ATPase domain, regulates the C5b-9 deposition and confers resistance to complement-dependent cytotoxicity. Significance: Mortalin is a potential therapeutic target in autoimmune diseases and in cancer immunotherapy. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.