Survival quantitative trait locus fine mapping by measuring and testing for hardy-weinberg and linkage disequilibrium

Abstract

I show that fine-scale localization of a survival-related locus can be accomplished on the basis of deviations from Hardy-Weinberg equilibrium and linkage disequilibrium at closely linked marker loci. The method is based on χ2-tests and they can be performed for age-specific samples of alive (or dead) individuals, as for combined samples of alive and dead individuals. Copyright © 2007 by the Genetics Society of America.