Journal ArticleOPEN ACCESS

An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2

Cell Reports (2020) 33(12)
DOI: 10.1016/j.celrep.2020.108528
60Citations
Citations of this article
81Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Tada et al. generate an ACE2 “microbody” in which the ACE2 ectodomain is fused to immunoglobulin heavy chain Fc domain 3. The ACE2 microbody protein potently inhibits the entry of SARS-CoV-2 spike protein pseudotyped virus into cells and replication of live SARS-CoV-2 in vitro and in a mouse model.

Author supplied keywords

Cite

CITATION STYLE

APA

Tada, T., Fan, C., Chen, J. S., Kaur, R., Stapleford, K. A., Gristick, H., … Landau, N. R. (2020). An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2. Cell Reports, 33(12). https://doi.org/10.1016/j.celrep.2020.108528

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free