PREDBALB/c: A system for the prediction of peptide binding to H2d molecules, a haplotype of the BALB/c mouse

Abstract

PREDBALB/c is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2d) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2d class I (H2-Kd, H2-Ld and H2-Dd) and class II (I-Ed and I-Ad) molecules. The prediction system utilizes quantitative matrices, which were rigorously validated using experimentally determined binders and non-binders and also by in vivo studies using viral proteins. The prediction performance of PREDBALB/c is of very high accuracy. To our knowledge, this is the first online server for the prediction of peptides binding to a complete set of major histocompatibility complex molecules in a model organism (H2d haplotype). PREDBALB/c is available at http://antigen.i2r.a-star.edu.sg/ predBalbc/. © 2005 Oxford University Press.