Preparation and Evaluation of Primidone Solid Lipid Nanoparticle for Alleviating Seizure Activity in Wistar Rats

Abstract

Introduction: In order to increase primidone’s anticonvulsant action, the study set out to manufacture it in solid lipid nanoparticle form (PRI-SLN). Method: Microemulsification and ultrasonication procedures were used to create 17 PRI-SLN formulations. Results: The PRI-SLN displayed a high entrapment efficiency (46.37 ± 2.42% to 81.82 ± 1.21%), as well as small particle size (149.9 ± 6.72 to 188.8 ± 5.25 nm). According to the in-vitro release study, PRI from SLNs releases more slowly than PRI by itself. The thermal analysis showed the drug’s compatibility with other substances and its presence in the more soluble amorphous state. Following a lethal and chronic dosage of picrotoxin, the PRI-SLN exhibited a higher anticonvulsant efficacy, according to in-vivo research on rats (p< 0.05). Conclusion: SLN with stronger anticonvulsant action can be made from PRI.