m.3243A

Abstract

OBJECTIVE-To study insulin sensitivity and perfusion in skeletal muscle together with the (3-cell function in subjects with the m.3243A 6.1% and newly found diabetes by OGTT (group 2), and seven with a previously diagnosed diabetes (group 3). Control subjects consisted of 13 healthy individuals who were similar to the carriers of m.3243A>G with respect to age and physical activity. (β-Cell function was assessed using the OGTT and subsequent mathematical modeling. RESULTS-Skeletal muscle glucose uptake was significantly lower in groups 1, 2, and 3 than in the control subjects. The glucose sensitivity of (β-cells in group 1 patients was similar to that of the control subjects, whereas in group 2 and 3 patients, the glucose sensitivity was significantly lower. The insulin secretion parameters correlated strongly with the proportion of m.3243A>G mutation in muscle. CONCLUSIONS-Our findings show that subjects with m.3243A