Phase II trial of the oral platinum comples JM216 in non-small-cell lung cancer: An EORTC early clincal studies group investigation

Abstract

Background: JM216 is a new oral platinum complex with doselimiting toxicity myelosuppresssion, now undergoing phase II evaluation. Patients and methods: JM216 was evaluated as first line therapy in non-smali-cell lung cancer. Seventeen patients received 120 mg'nr/day for five days repeated every three weeks. Results: Toxicity was manageable, the commonest sideeffects being nausea, vomiting, diarrhoea, constipation and asthenia. Myelososuppression was generally grade 2 and there were no cases of neutropenic sepsis or bleeding. Thirteen patients were fully évaluable for response. No sustained objective responses were reported. One patient was reported as stable disease had a partial response after three courses but was progressing again after four. An additional five patients had stable disease (46.2%). Conclusions: Although some patients may have had useful palliation, JM216 did not appear to have significant antiturnour activity in non-small-ceJl lung cancer. © 1997 Kluwer Academic Publishers.