Targeted isotretinoin in neuroblastoma: Kinetics, genetics, or absorption

Abstract

Isotretinoin (13-cis-retinoic acid; 13-cisRA) has been shown to significantly improve survival for children with high-risk neuroblastoma. Pharmacokinetics of isotretinoin may be negatively affected by the mode of drug administration and the dosing formula. © 2012 AACR.