Prefrontal cortex metabolome is modified by opioids, anesthesia, and sleep

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Abstract

Obtundation of wakefulness caused by opioids and loss of wakefulness caused by anesthetics and sleep significantly alter concentrations of molecules comprising the prefrontal cortex (PFC) metabolome. Quantifying state-selective changes in the PFC metabolome is essential for advancing functional metabolomics. Diverse functions of the PFC suggest the PFC metabolome as a potential therapeutic entry point for countermeasures to state-selective autonomic dysfunction.

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Lydic, R., & Baghdoyan, H. A. (2021). Prefrontal cortex metabolome is modified by opioids, anesthesia, and sleep. Physiology, 36(4), 203–219. https://doi.org/10.1152/PHYSIOL.00043.2020

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