ApoE4 polymorphism increases the risk for exercise-induced silent myocardial ischemia in older men

Abstract

The apolipoprotein (apo) E4 polymorphism is associated with increased risk for symptomatic coronary artery disease (CAD). This study examines whether the apoe4 allele is associated with an increased risk for exercise-induced silent myocardial ischemia (SI) in healthy, older (62±7 years; mean±SD), normocholesterolemic, nonsmoking male volunteers. The apoε4 allele was present in 20 of 45 (44%) men with SI on graded exercise treadmill testing compared with 22 of 127 (17%) men of comparable age with normal exercise tests (P