TP53 and Histone H3.3 Mutations in Triple-Negative Lower-Grade Gliomas

Abstract

Deletion of chromosome arms 1p and 19q and mutations in IDH and TERT define prognostic subgroups of low-grade gliomas. Gliomas without these lesions (triple-negative gliomas) are more common in China, often have TP53 mutations, and are associated with a worse prognosis.