Syntheses, crystal structures, and spectroscopic studies of aromatic ester derivatives of hexamolybdate

Abstract

Two new hybrids of local anesthetic analogs and polyoxometalates ((Bu 4N)2[Mo6O18NC6H 4COOCH3] (1) and (Bu4N)2[Mo 6O18NC6H4COOC2H 5] (2)} have been prepared in high purity and moderate yields using the easy reaction route of [α-MO8O26]4- with, corresponding aromatic amine hydrochlorides in the presence of a N,N′-dicyclohexylca:rbodiimide (DCC), and have been characterized by 1H NMR, IR, UV/Vis, ESI-MS, and single-crystal X-ray diffraction study. Compound 1 crystallizes in the triclinic space group P1̄ with dimer structure, while Compound. 2 crystallizes in the monoclinic space group P2 1/n with dimer and chain structure. These two hybrids have the typical Mo≡N triple bond that links a phenylimido group in local anesthetic analogs to the Mo atom of a hexamolybdate cluster. Because the formed Mo≡N bond is not stable in basic solution, this property is useful, and could be developed as a novel controlled-release technology for drug delivery. © Wiley-VCH Verlag GmbH & Co. KGaA.