A pattern-mixture model for the analysis of censored quality-of-life data

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Abstract

We propose a pattern-mixture model for describing the joint distribution of incomplete repeated measurements of quality of life (QoL) and right-censored survival times. The model assumes that the survival times follow a multinomial distribution and that the quality of life outcome follows a multivariate normal distribution conditional on the survival time. We estimate the model using a Bayesian approach by importance sampling. We then use simulated parameters to create multiple imputations of the censored QoL outcomes, which can then be used to calculate individual values of quality-adjusted life-years (QALYs). We apply the method to data from the Randomized Evaluation of Mechanical Assistance in the Treatment of Congestive Heart Failure (REMATCH) clinical trial. Copyright © 2006 John Wiley & Sons, Ltd.

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Li, H., & Heitjan, D. F. (2006). A pattern-mixture model for the analysis of censored quality-of-life data. Statistics in Medicine, 25(9), 1533–1546. https://doi.org/10.1002/sim.2482

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