Protective Effect of Arabic Gum on liver Injury Experimentally Induced by Gentamycin in Mice

Abstract

This research was conducted to evaluate the effect of Arabic gum (Ag) on hepatotoxicity induced by gentamycin in mice.    Forty adult male Bulb/c mice were used. The animal were divided into four groups (Gs) each group 10 animals. G1 considered as control, G2 treated with gentamycin(40mg/kg/day) for 8 days (i.p.). G3 treated with Ag (10 gm/kg/day) for 8 days administrated orally. Then G4 treated with both gentamycin and Ag for 8 days.    Biochemically, the results showed a significant decrease in levels  of serum ALT and AST in G4 as compared with G2 . Moreover, serum Glutathione (GSH) in G4 also elucidate a significant increasing  in its level, as well as a significant decrease in levels of malondialdihyde (MDA). Histopathologically, liver sections of  animals in G4 revealed an  ameliorative effects of Ag as compared with its compatible tissue sections of  G2. Liver of mice treated with    Ag (G3) showed an apoptosis in hepatocytes.    In conclusion, treatment of hepatotoxicity by Arabic gum , showed melioration in histopathological changes in hepatic tissues in addition to have ability for induction of apoptosis and meliorating liver picture.