A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

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Abstract

Abstract: One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8 ± 13.3% at the dose of 30 mg/kg/day. Graphic Abstract: [Figure not available: see fulltext.].

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Wu, X. R., Shen, Y., Cui, S. J., Luo, X. L., Xiao, C. J., & Jiang, B. (2020). A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi. Natural Products and Bioprospecting, 10(2), 101–104. https://doi.org/10.1007/s13659-020-00234-4

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