Abstract
Biotransformation of the diterpene jatrophone (1) by Aspergillus niger ATCC 16404 afforded the new diterpene 9β -hydroxyisabellione (2). The compounds were characterized by spectroscopic analysis. The cytotoxicity of the compounds as IC50 values on AGS and lung fibroblasts was 2.4 and 2.8 μM for compound 1 and 53.1 and 260 μM for 2, respectively. Microbial transformation of 1 into compound 2 strongly reduced the cytotoxicity and enhanced the selectivity against AGS cells. © 2007 Verlag der Zeitschrift für Naturforschung.
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Pertino, M., Schmeda-Hirschmann, G., Santos, L. S., Rodríguez, J. A., & Theoduloz, C. (2007). Biotransformation of jatrophone by aspergillus niger ATCC 16404. Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences, 62(2), 275–279. https://doi.org/10.1515/znb-2007-0221
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