Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4 + T Cells and Offers an Opportunity to Tackle Infection

Abstract

Targeting HIV reservoirs remains a challenge. Valle-Casuso et al. found that HIV-1 selectively infects highly metabolic CD4 + T cells, independent of their activation phenotype. Inhibition of metabolic pathways blocks the early steps of HIV-1 replication and induces death of infected cells, highlighting a metabolic vulnerability that can be therapeutically exploited.