Estimation of beta two microglobulins, Fetuin-A, resistin serum level in iraqi multiple myeloma patients

Abstract

Multiple myeloma is hematological disease produces many complications in the bone, kidney, neural and other complications. The study aims to measure serum biomolecules like fetuin-A and resistin and determined the possibility to use these biomarkers as disease predictor. blood samples were isolated from 58 patients and 24 sex and age-matched control, serum then isolated, and proper ELISA kit then used to a determined level of β2 microglobulin, resistin, and fetuin-A. The result demonstrated significant increase in β2 microglobulin, fetuin-A and resistin in patients compare to control (1.347±0.714 vs. 0.913±0.253), p = 0.000, (14.003±10.352 vs. 9.259±4.264), p= 0.005, (1.967±3.595 vs. 0.604±0.622), p = 0.009, respectively. These differences give the possibility to use these biomolecules as a predictor in multiple myeloma.