Dysfunction of tubular phosphate reabsorption related to glomerular filtration and blood glucose control in diabetic children

Abstract

The renal handling of inorganic phosphate was studied by measuring the urinary excretion rate of phosphate ( {Mathematical expression}), phosphate-(Cr51) EDTA clearance ratio ( {Mathematical expression}) and maximal tubular reabsorption of phosphate per litre glomerular filtrate ( {Mathematical expression}) during fasting in 26 ambulatory Type 1 (insulin-dependent) diabetic children without clinical signs of microangiopathy (age: 7-14 years; duration of disease: 3-14 years). Similar measurements were made in 28 healthy schoolchildren (age: 8-14 years). {Mathematical expression} and {Mathematical expression} were significantly enhanced in the diabetic children (p<0.001) and correlated with the degree of hyperglycaemia (p<0.005). {Mathematical expression} was significantly suppressed in the diabetic children (1.23 versus 1.73 mmol/1, p<0.001). This disturbance was neither related to changes in serum parathyroid hormone nor to growth hormone concentrations but was inversely correlated with the degree of hyperglycaemia (r=-0.61, p<0.001) and with tubular reabsorption of glucose in the diabetic subjects, the mean maximal ( {Mathematical expression}) and absolute tubular phosphate reabsorption rates were equal to those of the 28 healthy subjects. Both in the diabetic and healthy subjects, these parameters were positively correlated with glomerular filtration rate which was significantly elevated in the diabetic children (138 versus 109 ml/min per 1.73 m2, p<0.01). The study demonstrates a dysfunction in tubular phosphate reabsorption in diabetic children which is related to glycaemic regulation. © 1982 Springer-Verlag.