Efeitos antioxidantes do selênio e seu elo com a inflamação e síndrome metabólica

Abstract

The mild chronic inflammation and oxidative stress associated with metabolic syndrome are relevant risk factors for the development of cardiovascular diseases. In this context, selenium is an essential mineral associated with the correct functioning of the main metabolic processes of the cell. In vitro and in vivo studies in experimental metabolic syndrome models as well as in humans have investigated the effect of selenium on the expression and secretion of inflammation and oxidative stress biomarkers. Articles on the antioxidant effects of selenium were sought in scientific websites. There are a great number of studies in the literature on the different parameters modulated by blood selenium levels, such as C-reactive protein, interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta and retinol binding protein 4. The objective of this review is to discuss the role of selenium in inflammatory and oxidative stress processes associated with the metabolic syndrome.