Synthesis and antimycobacterial activities of certain trifluoromethyl- aminoquinoline derivatives

Abstract

A number of 4-amino substituted 2,8-bis(trifluoromethyl)quinoline derivatives were synthesized and evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis (M. tb) strain H37Rv. Preliminary results indicated that most of the compounds demonstrated better in vitro antimycobacterial activity, and are comparable to the first line antituberculosis drugs. The most effective compound 1 of the series has a MIC of 3.13 μg/ml, IC50 value of 3.9. The objective of our study is to generate new leads and to optimize their structure to display the potent efficacy. ©ARKAT.