An Overview of Some Plant Based Products With Hepatoprotective Activity(A review)

Abstract

In folk medicine there are various medicinal amalgamation possessing hepatoprotective activity. Toxins may cause liver insult as well. Hence, many pharmaceutical companies are targeting herbal medicines for the treatment of liver abnormalities and towards evolving a safe and effective formulation with desired route of administration. Review focused on the studies showing hepatoprotective effect using marine compounds and plant derived compounds. Liver disorder, a global health problem, usually include acute or chronic hepatitis, heptoses, and cirrhosis. It may be due to toxic chemicals and certain antibiotics. Uncontrolled consumption of alcohol also affects liver in an unhealthy way. To cure liver disorders several formulations of medicinal plants are being used. It is observed that hepatoprotective effect of plant is mostly due to flavonoids, alkaloids, terpenoids, steroids, and glycoside. A single drug cannot be useful for all the types of liver disorders. Therefore, several plant extracts for liver illness resulting fromdifferent causes such as poisonous chemicals, viruses, extra alcohol consumption, and repeated administration of medication is to be considered. By using standards of protection and efficacy, manufacture of plant products need to be taken into consideration. Current review provides an understanding of ethnopharmacology and toxicology of several medicinal plants manifesting hepatoprotective potential. Despite of varied database analysis new discoveries and their probabilities, evidences on viral hepatitis treatment and/or liver cirrhosis are inadequate. Further information about phytotherapy, toxicology, quality control studies shall be endorsed. Further in depth studies are required to discover quality trait like structure activity relationship, mechanism of action, safety and toxicity and therapeutic potential of phytoconstituents in clinical settings. Aim: The phytoconstituents studied for their protective effect in liver diseases are reviewed.