Abstract
T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation.
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CITATION STYLE
Barbarulo, A., Lau, C. I., Mengrelis, K., Ross, S., Solanki, A., Saldaña, J. I., & Crompton, T. (2016, September 1). Hedgehog signalling in the embryonic mouse thymus. Journal of Developmental Biology. MDPI Multidisciplinary Digital Publishing Institute. https://doi.org/10.3390/jdb4030022
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