Multifunctional and Scalable Nanoparticles for Bimodal Image-Guided Phototherapy in Bladder Cancer Treatment

Abstract

Pyropheophorbide a–bisaminoquinoline conjugate lipid nanoparticles (PPBC LNPs), formulated with lipid-based excipients and assembled using microfluidics, exhibit excellent biocompatibility and stability, indicating promise for clinical applications. PPBC LNPs possess remarkable photoacoustic and fluorescence imaging capabilities, enabling high-resolution, deep tissue penetration and high sensitivity imaging for tracking drug biodistribution and phototherapy efficacy.