Design, synthesis, and evaluation of analogues of (+)-14- normethyldiscodermolide

Amos B. Smith; B. Scott Freeze; Matthew J. LaMarche; Tomoyasu Hirose; Ignacio Brouard; Ming Xian; Kurt F. Sundermann; Simon J. Shaw; Mark A. Burlingame; Susan Band Horwitz; David C. Myles

Journal Article

Design, synthesis, and evaluation of analogues of (+)-14- normethyldiscodermolide

Organic Letters (2005) 7(2) 315-318

DOI: 10.1021/ol0476873

35Citations

12Readers

Get full text

Abstract

(Chemical Equation Presented) The design, syntheses, and biological evaluation of nine totally synthetic analogues of the microtubule-stabilizing agent (+)-14-normethyldiscodermolide (2) are reported. Simplification at the C(21)-C(24) terminal diene and at the C(1)-C(5) lactone moieties reveals significant structure-activity relationships.

Cite

CITATION STYLE

APA

Smith, A. B., Freeze, B. S., LaMarche, M. J., Hirose, T., Brouard, I., Xian, M., … Myles, D. C. (2005). Design, synthesis, and evaluation of analogues of (+)-14- normethyldiscodermolide. Organic Letters, 7(2), 315–318. https://doi.org/10.1021/ol0476873

Design, synthesis, and evaluation of analogues of (+)-14- normethyldiscodermolide

Abstract

Cite

Register to see more suggestions