Impact on acute myeloid leukemia relapse in granulocyte colony-stimulating factor application: a meta-analysis

Abstract

Objectives: This meta-analysis evaluated the impact of granulocyte colony-stimulating factor (G-CSF) added to chemotherapy on treatment outcomes including survival and disease recurrence in patients with acute myeloid leukemia (AML). Methods: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until 19 September 2016 using search terms. Studies that investigated patients with AML who underwent stem-cell transplantation were included. Results: The overall analysis revealed a significant improvement in overall survival (OS) (P =.019) and disease-free survival (DFS) (P =.002) for patients receiving G-CSF with chemotherapy. Among patients without prior AML treatment, there was a significant improvement in DFS (P =.014) and reduction in incidence of relapse (P =.015) for those who received G-CSF. However, subgroup analyses found no significant difference between G-CSF (+) and G-CSF (−) treatments in rates of OS (P =.104) and complete remission (CR) (P =.572) for patients without prior AML treatment. Among patients with relapsed/refractory AML, there was no significant difference found between G-CSF (+) and G-CSF (−) groups for OS (P =.225), DFS (P =.209), and CR (P =.208). Discussion: Treatment with chemotherapy plus G-CSF appears to provide better survival and treatment responses compared with chemotherapy alone, particularly for patients with previously untreated AML. Abbreviations: AML, acute myeloid leukemia; CI, confidence interval; CR, complete remission; DFS, disease-free survival; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte macrophage colony-stimulating factor; HR, hazard ratio; MDS, myelodysplastic syndrome; OR, odds ratio; OS, overall survival; RCTs, randomized control trials; RR, relative risk.