Use of phytoestrogen with clomiphene citrate for ovulation induction in polycystic ovary syndrome

Abstract

The goal of this study is to assess the effectiveness of phytoestrogen with clomiphene citrate for ovulation induction in women with polycystic ovarian syndrome to overcome the antiestrogenic effect of clomiphene citrate on endometrium, were randomly grouped into two groups, 50 in each group. Group 1: receiving CC 100 mg twice daily from third day of cycle for five days and group 2: receiving CC from 3rd of cycle for 5 days plus phytoestrogen (Klimadynon(®), Bionorica, Neumarkt i.d.OBf., Germany) (20mg of cimifuga racemosa from day 1to12). Women receiving CC plus phytoestrogen have increase number of dominant follicles, endometrial thickness with improvement of both ovulation rate and pregnancy rate.