Antimelanomal activities of some newly synthesized pyrrolotriazolopyrimidines and pyrrolotetrazolopyrimidines and their derivatives

Abstract

A series of pyrrolo[2,3-d]pyrimidine, pyrrolotriazolopyrimidine and pyrrolotetrazolopyrimidine derivatives 2-13 were synthesized using 2-amino-1-(3-(trifluoromethyl)phenyl)-4,5-bis (4-methoxy-phenyl)-1H-pyrrole-3-carbonitrile 1 as starting material. The biological rational upon which the newly synthesized compounds was built was their structural similarity with some pyrrole derivatives that having antimelanomal, anti-tetrahymena and some kinases inhibitor activities. Some of the newly synthesized compounds showed antimelanomal, anti-tetrahymena and some kinases inhibitor activities of the 124 kinases panel.