Anti-Golgi Antibody as a Potential Indicator for Rheumatoid Arthritis

Abstract

Objective: To reveal the relationship between anti-Golgi antibody (AGA) and clinical diseases through retrospective analysis. Methods: The clinical data of 584 cases testing positive for AGA in the past 11 years were collected and retrospectively analyzed. Results: AGA pattern accounted for .2% of positive ANA results. In total, 35.0% of diagnosed patients had autoimmune diseases (AID), mainly rheumatoid arthritis (RA). High-titer AGA (≧1:1000) was common in AID. In nondiagnosed patients with clinical symptoms, joint pain/muscle pain was the most common. Conclusions: Positive AGA with high titer was closely related to RA. Joint pain/muscle pain was the most common symptom in patients who tested AGA positive. Therefore, AGA may be a key indicator of RA in the Chinese population.