Subclinical rhythmic electrographic discharge of adults (SREDA) in a case with spinocerebellar degeneration improved clinically by thyrotropin-releasing hormone

Abstract

Herein, we report on a patient with spinocerebellar degeneration who exhibited subclinical rhythmic electrographic discharge of adults (SREDA). Thyrotropin-releasing hormone (TRH) improved the clinical symptoms and SREDA was observed only when administration of thyrotropin-releasing hormone was discontinued and the symptoms worsened. Furthermore, after resuming administration of taltirelin hydrate, a TRH analog, the improvement in motor function was accompanied by a decrease in delirium. It is plausible that taltirelin hydrate improved the distorted cerebral blood flow, which has been reported previously as the mechanism underlying SREDA, as a consequence of the functional improvement in neurotransmitter systems. © 2009 The Authors Journal compilation © 2009 The Japanese Psychogeriatric Society.