Abstract
Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20 column chromatography and reversed phase HPLC. Funalenone inhibited 50 of type I collagenase activity at a concentration of 170 μM, but inhibited 18.3 and 38.7 against 72 kDa and 92 kDa type IV collagenase, respectively, at a concentration of 400 μM.
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CITATION STYLE
Inokoshi, J., Shiomi, K., Masuma, R., Tanaka, H., Yamada, H., & Omura, S. (1999). Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. Journal of Antibiotics, 52(12), 1095–1100. https://doi.org/10.7164/antibiotics.52.1095
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