Production of Menaquinone (Vitamin K2)-5 by a Hydroxynaphthoate-resistant Mutant Derived from Flavohacterium meningosepticum, a Menaquinone-6 Producer

Abstract

A 1-hydroxy-2-naphthoate-resistant mutant, strain HNA 12-D, which was derived from a menaquinone (MK)-6 producer, Flavobacterium meningosepticum IFO 12535, produced an increased amount of MK with the production of another type of MK in addition to MK-6. The newly formed MK was isolated and identified as MK-5. The total amount of MK reached 55.6 mg/liter of culture broth and 9.19mg/g dry cells in the ratio of MK-6 and MK-5 of 1:1.7. Copyright © 1985, Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.