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Defective sterol Δ 5(6) desaturase as a cause of azole resistance in Ustilago maydis

  • Joseph-home T
  • Manning N
  • Hollomon D
  • et al.
FEMS Microbiology Letters (1995) 127(1-2) 29-34
DOI: 10.1111/j.1574-6968.1995.tb07445.x
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Abstract

Resistance to azole antifungals in Ustilago maydis was associated with a leaky defect in sterol delta 5(6)desaturase. This defect resulted in reduced accumulation of 14 alpha-methylergosta-24(28)-diene-3 beta,6 alpha-diol and an increase in the proportion of 14 alpha-methylfecosterol in treated cells when compared to the parent strain. The results demonstrate the importance of this mechanism in pathogenic fungi.

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Joseph-home, T., Manning, N. J., Hollomon, D., & Kelly, S. L. (1995). Defective sterol Δ 5(6) desaturase as a cause of azole resistance in Ustilago maydis. FEMS Microbiology Letters, 127(1–2), 29–34. https://doi.org/10.1111/j.1574-6968.1995.tb07445.x

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