Preparation and characterization of quetiapine fumarate loaded transfersome as a novel drug delivery system

Abstract

Modern medicine delivery techniques like transdermal patches are vital for treating numerous disorders. With the aid of TDDS, first pass metabolism is prevented, which aids in achieving effective bioavailability. Drug molecules are also released into the systemic circulation at a controlled and predetermined rate. The objective of this study was creating matrix-type Quetiapine fumarate loaded transdermal patches with water bath method using different polymers like HPMC 5 cps, HPMC 15 cps, and Ethyl cellulose in different ratios. Polyethylene glycol-400, Dimethyl sulfoxide (DMSO) as a plasticizer and permeation enhancer, Solvents including methanol and chloroform in 1:1 ratio employed. FT-IR study indicated that pure drug and excipients are compatible with each other. The formulated patches are evaluated for thickness, weight variation, folding endurance, percentage moisture content, percentage moisture uptake, drug content and In vitro diffusion studies. A transfersomal formulation containing 25 mg of the drug and 10 mg of span 80 was concluded as the optimized formulation (F1) as it showed maximum drug entrapment (84.8%) and cumulative percent drug release (98.51%)