The effects of calcium-antagonists on lower esophageal sphincter pressure —he Possiblity of Application of Nffedipine to Achalasia—

Abstract

Calcium-antagonists causes smooth muscle relaxation by the prevention of intra-cellular influx of calcium ions. In this study, the effects of calcium-antagonists on lower esophageal sphincter pressure (LESP) were investigated both basically and clinically. In the study of basic investigation using anesthetized dogs, nifedipine, verapamil and diltiazem decreased resting LESP and inhibited the rise of LESP by tetragastrin or bethanechol. In the clinical experiment, author intended to apply the depressant effect of calcium-antagonists to LESP-increased state, achalasia, nifedipine which is able to administer sublingually was investigated in achalasia patients. By the administration of nifedpine, LESP of achalasia patients were decreased and the symptoms were relieved. Therefore, nifedipine will be a possible aid of medical treatment of achalasia. © 1982, The Japanese Society of Gastroenterology. All rights reserved.